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Cancer cachexia not only negatively affects the quality of life of patients, but is also associated with a reduced efficacy and increased toxicity of chemotherapy, thereby contributing to mortality [34]

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It binds GLP-1 receptors on microglia, suppressing pro-inflammatory cytokines and preventing astrocyte transformation into neurotoxic phenotypes, which reduces neuroinflammation and preserves neuronal and synaptic integrity [39,40]

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